The Potential of Cell Sheet Technology for Beta Cell Replacement Therapy
نویسندگان
چکیده
Abstract Purpose of Review Here, we review the use cell sheet technology using different types and its potential for restoring extracellular matrix microenvironment, perfusion, immunomodulatory action on islets beta cells. Recent Findings Cell sheets can be produced with fabrication techniques ranging from widely used temperature responsive system to magnetic system. A variety cells have been produce including skin fibroblasts, smooth muscle cells, human umbilical vein endothelial mesenchymal stem Summary CST would allow recreate ECM which provide cues support islet survival improvement function. Depending type, additional supporting properties like immunoprotection or better revascularization could provided. Furthermore, offers possibility other implantation sites than inside liver. Further research should focus thickness size generate a translational therapy.
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ژورنال
عنوان ژورنال: Current Transplantation Reports
سال: 2022
ISSN: ['2196-3029']
DOI: https://doi.org/10.1007/s40472-022-00371-4